Gene expression

Gene expression (also protein expression or often simply expression) is the process by which a gene's information is converted into the structures and functions of a cell. Gene expression is a multi-step process that begins with transcription and translation and is followed by folding, post-translational modification and targeting. The amount of protein that a cell expresses depends on the tissue, the developmental stage of the organism and the metabolic or physiologic state of the cell.

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Measurement

Indirectly, the expression of particular genes may be assessed with microarray technology, which can provide a rough measure of the cellular concentration of different mRNAs; often thousands at a time. While the name of this type of assessment is actually a misnomer, it is often referred to as expression profiling. (The expression of many genes is known to be regulated after transcription, so an increase in mRNA concentration need not always increase expression.)

Control of expression

Control of gene expression depends various factors including:

Overexpression

The protein encoded for by a gene can be expressed in increased quantity. This can come about by:

  • increasing the number of copies of the gene
  • increasing the binding strength of the promoter region

Gene networks and expression

Main article: Gene regulatory network

Genes have sometimes been regarded as nodes in a network, with inputs being proteins such as transcription factors, and outputs being the level of gene expression. The node itself performs a function, these and the operation of these functions have been interpreted as performing a kind information processing within cell and determine cellular behaviour.

See also

External links


de:Genexpression

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